Hairgenics Pronexa Hair Regrowth Shampoo – Review – Hair Loss Shampoo with DHT Blocker

Hairgenics Pronexa Hair Regrowth Shampoo – Review – Hair Loss Shampoo with DHT Blocker

Review of Hairgenics Pronexa Hair Regrowth Shampoo
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One of the main reasons we lack an effective way to prevent hair loss is that we still understand bafflingly little about the molecular mechanisms that underpin human hair growth and loss. Each hair follicle on our scalp is a miniature organ, which follows its own rhythmic cycle of growth, regression and rest throughout our lifetimes.

With age, some of them become sensitive to hormones on the scalp, most notably Dihydrotestosterone or DHT, which binds to the follicles and miniaturises them until they no longer produce visible hair. However, we know hardly anything about how this miniaturisation process happens, or how to prevent it.

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According to Prof Ralf Paus, a dermatologist at the University of Manchester, this is because hair loss is still viewed largely as a cosmetic problem, rather than a disease. Because of this, in the western world, neither industry nor academic funding bodies have been willing to spend substantial sums of money on hair research.

Despite the scale of patient demand, they have been dissuaded by the knowledge that any drug that hits the market is unlikely to be covered by the NHS or insurance companies.

“If you look at the sums pharma companies have spent on coming up with new cancer or heart disease drugs, this is in the billions,” Paus says. “These investments have just not been made into serious hair research.”

Though hair loss may have an undoubtable psychological impact on sufferers, it can’t be compared with chronic life-threatening diseases, many of which are incurable.

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»» Reviving Existing Hair Follicles

Rather than trying to grow completely new follicles, Paus thinks we should focus our efforts on trying to revive the ones we already have. He points out that even completely bald individuals still have 100,000 hair follicles all over their scalp. You just can’t see them.

“They’re miniaturised, so instead of making a normal long hair shaft, they only make a tiny, microscopically visible one,” he says. “But the organ is still there. So in order to solve the balding problem, we don’t need a single new hair follicle, we just need to get the ones already there to do their job properly again. If we could retransform these miniaturised follicles into big ones, we wouldn’t need a single hair transplant.”

Over the last four years, Paus has been exploring one particularly innovative way of doing this. There are a small handful of drugs, such as the immuno suppressant cyclosporine, which cause unwanted hair growth as a side-effect. By studying this, Paus’s research group has identified a completely new pathway for stimulating hair follicles.

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“This [has] allowed us to discover some basic hair-growth control principles which could be used to find a completely new class of hair drugs,” he says.

They have since found a series of compounds that appear to be highly effective at stimulating this pathway and inducing hair growth when tested on human hair follicle cells in the lab. If safe enough, they could soon be trialled as a new topical treatment in volunteers.

As a result, while the holy grail of hair loss – preventing it completely – still remains a distant vision, there are enough promising treatments in the pipeline to allow even the baldest individuals to dream of new hair.

For scientists, especially those in the western world, the hope is simply that such breakthroughs will encourage new investment in the field.

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“Hair is one of our most important social communication instruments, so new treatments are a huge market, a multimillion-dollar market that keeps growing,” says Paus.

“There’s a vast economic potential from serious breakthroughs in hair research. But there needs to be more funding from government and industry to make them happen. That realisation hasn’t really happened yet.”

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