Alopecia Barbae
Alopecia Barbae: Facts about Baldness
Alopecia Barbae is also called baldness. This is the exceedingly recognized ailment encountered by many today. The victims of this disorder belong to both genders. However, research reveals that the causative agents of Alopecia Barbae are responsible for the apparently different effects too in men and women.
Baldness is widespread across the globe, victimizing 50% of males and a similar percentage of females above the age of 40 years. However, in this group of females, 13% of premenopausal patients express only slight signs of the disease. Nonetheless, the chances of falling prey to Alopecia Barbae increases after menopause that 75% women over the age of 65 years of age get affected by this problem. Before reaching the age of 40 years, the sufferers bear signs of Alopecia Barbae, and some depict this even before they turn 30.
Alopecia is a psychological torment for the sufferers. Hair loss allows the head to be exposed to the UV rays, giving rise in actinic infliction. Cardiac ailments could be accelerated by Alopecia in males, and increase in mild prostatic hypertrophy could be associated with this problem too. If the ongoing research studies evidence that the above relations are valid, then the clinical implications with Alopecia would increase too.
White males are the most affected by baldness in terms of frequency and severity while the second most affected are Asians and African Americans. The least affected are Native Americans and Eskimos.
Onset of the Ailment
Alopecia Barbae begins slowly. In men, it starts with hair loss in the temporal region which reshapes the posterior hairline. Then, it develops with the usual anterior and apex hair loss. While in case of women, it begins with scattered hair loss in the crown. The temporal hair loss is similar to men, but generally, females retain their anterior hairline.
Physical Changes
The sufferers of both genders experience the transition from healthy, pigmented terminal hair to weak, short and scattered hair. The end result is stunted, flimsy, non-pigmented hair in the affected areas. With time, the anagen step decreases while the telogen part is unaffected. It gives rise to the hair fall among the victims. Though it provides a generalized picture, the differences in the development of ailment always persist among different individuals. In case of females, usually, the patch of hair loss cannot be specified. Generally they lose hair in all areas over the crown. The core difference is that the anterior hairline is safe in case of females while that is lost right at the onset of the problem in case of males.
Research Findings
Androgenetic Alopecia is a hereditary disease, which is quite capable of expressing itself right at the startup. To cure this abnormality, Androgen is essentially required. The progress of this ailment could be controlled if the post pubertal men are castrated. The recent experiments on immuno-deficient mice depicted that the follicle cells from balding areas are capable of growing terminal hair. And this discovery promises a progress in the reversal of the affliction.
The research showed that the hedgehog family of intercellular signaling proteins is capable of supporting the transition from the telogen stage to the anagen of the hair cycle. However, the promises of the researches in this arena still remain a moot question as of today!
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May 28th, 2010 at 3:04 am
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